Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation.

摘要: Activation of blood coagulation, as characterized by the occurrence disseminated intravascular increased levels plasma FPA, and local deposition fibrin, is common in both experimental animals patients with malignant tumors. Many mechanisms have been proposed for mediation this response to tumors, including tumor-associated proteases, platelet adherence surface activation coagulation tumor cells, tissue factor derived from either or reactive leukocytes. We investigated hypothesis that MTF generation may contribute fibrin cancer patients. Plasma FPA vitro unstimulated were measured simultaneously samples obtained 35 lung cancer. significantly elevated these compared a group 20 normal volunteers (p = 0.03). Although showed considerable variability volunteers, high degree correlation was observed between simultaneous regardless whether expressed per cell (r 0.83), monocyte 0.95), volume peripheral 0.96). also decreased receiving sodium warfarin less than 0.001). These results suggest potential role neoplasia possibility inhibition be partially responsible values previously reported anticoagulated