The involvement of protein kinase G in stimulation of neutrophil migration by endothelins

摘要: Abstract Activation of human neutrophil migration by endothelin-1 and endothelin-3 is inhibited guanylate cyclase inhibitors, antagonists protein kinase G (G-kinase), KT-5823, an inhibitor G-kinase. Although no direct effect endothelins on cGMP level could be established, these results suggest that the mediated cGMP, proceeds via a There was little or inhibitors G-kinase endothelin-2-activated migration, indicating role in endothelin-2-induced activation either absent at least different from other endothelins. As compared with activators, formyl-methionyl-leucyl-phenylalanyl-(fMLP-)activated resembled endothelin-activated while interleukin-8- leukotriene B 4 -activated less pronounced.