THE EFFECT OF ENDOTHELIN-2 (ET-2) ON MIGRATION AND CHANGES IN CYTOSOLIC FREE CALCIUM OF NEUTROPHILS
作者： Jan G.R. Elferink , Ben M. de Koster
DOI: 10.1007/BF00168749
关键词:
摘要: The effect of endothelin-2 (ET-2) on neutrophil migration and intracellular calcium was studied. Depending the concentration, ET-2 enhanced or inhibited migration. At low concentrations caused a chemotactic stimulation migration, in contrast with endothelin-1 (ET-1) which chemokinetic higher formyl-methionylleucyl-phenylalanine(fMLP)-activated Both activation inhibition by were completely dependent extracellular Ca2+. Unlike ET-1 an increase cytosolic free Ca2+ at concentration stimulated measurable did not stimulate This strongly suggests that there is no correlation between maximal cytoplasmic calcium, Influx required for both change Ca+, because observed absence blockers Ca2+-influx ET-2-activated ETA-receptor antagonist cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) (BQ123), ETB-receptor [Cys11-Cys15]-endothelin-1(11–21) (IRL1038) antagonized stimulatory inhibitory high fMLP-activated chemotaxis. are involved ET-2, ET-2.
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