Chlorogenic Acid Inhibits the Replication and Viability of Enterovirus 71 In Vitro
作者： Xiang Li , Yuanyuan Liu , Xueling Hou , Hongjun Peng , Li Zhang
DOI: 10.1371/JOURNAL.PONE.0076007
关键词:
摘要: Enterovirus 71 (EV71) is an etiology for a number of diseases in humans. Traditional Chinese herbs have been reported to be effective treating EV71 infection. However, there no report about the antiviral effects CHA against EV71. In this study, plaque reduction assay demonstrated that inhibitory concentration 50% (IC50) on replication 6.3 µg/ml. When both (20 µg/ml) and were added, or added post-infection at different time points, was able effectively inhibit between 0 10 h. addition, inhibited 2A transcription translation EV71-infected RD cells, but did not affect VP1, 3C, 3D expression. Furthermore, secretions IL-6, TNF-α, IFN-γ MCP-1 cells. Altogether, these results revealed may properties
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Débora D Lückemeyer, Vanessa DM Müller, Maria Izabel G Moritz, Patricia H Stoco, Eloir P Schenkel, Célia RM Barardi, Flávio H Reginatto, Cláudia MO Simões, None, Effects of Ilex paraguariensis A. St. Hil. (Yerba Mate) on Herpes Simplex Virus Types 1 and 2 Replication Phytotherapy Research. ,vol. 26, pp. 535- 540 ,(2012) , 10.1002/PTR.3590
F. Mineau, J.-P. Pelletier, Mengkun Zhang, F. C. Jolicoeur, D. V. Jovanovic, Yulan He, J. A. Di Battista, J. Martel-Pelletier, IL-17 STIMULATES THE PRODUCTION AND EXPRESSION OF PROINFLAMMATORY CYTOKINES, IL-BETA AND TNF-ALPHA , BY HUMAN MACROPHAGES Journal of Immunology. ,vol. 160, pp. 3513- 3521 ,(1998)
Juliet M. Morrison, Vincent R. Racaniello, Proteinase 2Apro Is Essential for Enterovirus Replication in Type I Interferon-Treated Cells Journal of Virology. ,vol. 83, pp. 4412- 4422 ,(2009) , 10.1128/JVI.02177-08
Mahmud Tareq Hassan Khan, Arjumand Ather, Kenneth D Thompson, Roberto Gambari, None, Extracts and molecules from medicinal plants against herpes simplex viruses Antiviral Research. ,vol. 67, pp. 107- 119 ,(2005) , 10.1016/J.ANTIVIRAL.2005.05.002
Peter J. King, Guoxiang Ma, Wenfang Miao, Qi Jia, Brenda R. McDougall, Manfred G. Reinecke, Chris Cornell, Jean Kuan, Tracey R. Kim, W. Edward Robinson, Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication. Journal of Medicinal Chemistry. ,vol. 42, pp. 497- 509 ,(1999) , 10.1021/JM9804735
Xiaoming Chen, Qian Zhang, Jinghua Li, Wei Cao, Jin-Xia Zhang, Lei Zhang, Weilu Zhang, Zhong-Jun Shao, Yongping Yan, Analysis of recombination and natural selection in human enterovirus 71. Virology. ,vol. 398, pp. 251- 261 ,(2010) , 10.1016/J.VIROL.2009.12.007
Kan X. Wu, Mary M.-L. Ng, Justin J.H. Chu, Developments towards antiviral therapies against enterovirus 71. Drug Discovery Today. ,vol. 15, pp. 1041- 1051 ,(2010) , 10.1016/J.DRUDIS.2010.10.008
Hirotoshi Tamura, Takashi Akioka, Koichi Ueno, Takeshi Chujyo, Katsu-ichiro Okazaki, Peter J. King, W. Edward Robinson, Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves Molecular Nutrition & Food Research. ,vol. 50, pp. 396- 400 ,(2006) , 10.1002/MNFR.200500216
David N. Irani, ASEPTIC MENINGITIS AND VIRAL MYELITIS Neurologic Clinics. ,vol. 26, pp. 635- 655 ,(2008) , 10.1016/J.NCL.2008.03.003
Chien-Hui Hsu, Chun-Yi Lu, Pei-Lan Shao, Ping-Ing Lee, Chuan-Liang Kao, Ming-Yi Chung, Luan-Yin Chang, Li-Min Huang, Epidemiologic and clinical features of non-polio enteroviral infections in northern Taiwan in 2008. Journal of Microbiology Immunology and Infection. ,vol. 44, pp. 265- 273 ,(2011) , 10.1016/J.JMII.2011.01.029