Recombinant Therapeutic Human Monoclonal Antibodies
作者： J. W. Larrick , R. Balint
DOI: 10.1007/978-3-642-78432-3_2
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摘要: Cell fusion techniques have made the generation of rodent monoclonal antibodies (MABs) a routine endeavor (Kohler and Milstein 1975). As early as 1975 first investigators this technology recognized therapeutic industrial potential MABs, particularly human (huMABs), yet 18 years later only OKT3 — an anti-T lymphocyte antigen (CD3) murine MAB is licensed drug. There are two reasons for apparent lack progress: target selection technical difficulties. Despite modest beginning large number MABs generated primarily by cell in clinical development (see below). Recent advances using recombinant DNA alleviated many problems with will accelerate huMABs (Larrick et al. 1987).
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