Amphipathic nucleic acid transporter

摘要: A nucleic acid transporter to deliver a acids into cells, comprising cationic compound having head group for binding the and lipid tail association with membrane. usually is polyamine or short basic peptide. The selected from consisting of plant steroid, animal isoprenoid compound, aliphatic lipid, pore forming protein, peptides fusogenic peptides. are linked through carbamate linkage. When used, it preferably either spermidine spermine can be any variety, including triplex oligonucleotides, antisense oligonucleotide, aptamers, ribozymes, plasmids DNA gene therapy. Also described method treating individuals using therapeutic acid.