Further evidence for a locus for cutaneous malignant melanoma-dysplastic nevus (CMM/DN) on chromosome 1p, and evidence for genetic heterogeneity.

摘要: Assignment of a susceptibility locus for cutaneous malignant melanoma-dysplastic nevus (CMM/DN) to chromosome 1p remains controversial. We examined the relationship between CMM/DN and markers D1S47, PND, D1S160 on seven new families (set B) plus updated versions six previously reported A). Three linkage analyses were performed: (1) CMM alone--all individuals without confirmed melanoma or borderline lesions considered unaffected (model I); (2) with variable age at onset sporadics II); (3) using model Bale et al. III). For alone Zmax = 3.12 theta .10. alone, 1.76 PND showed no evidence alone. Models II III strong D1S160, in set A pedigrees but not B families. tested homogeneity II) by splitting into two groups basis proportion cases occurrence immune-related tumors. In group 1 there was significant heterogeneity both D1S47 2 D1S160. Thus, diagnostic, clinical, genetic are likely reasons that previous studies have failed confirm 1p. The results linked as well only subset appearing