Role of Helicobacter pylori cagA(+) strains and specific host immune responses on the development of premalignant and malignant lesions in the gastric cardia.
作者： Richard M. Peek , Michael F. Vaezi , Gary W. Falk , John R. Goldblum , Guillermo I. Perez-Perez
DOI: 10.1002/(SICI)1097-0215(19990812)82:4<520::AID-IJC9>3.0.CO;2-7
关键词:
摘要: The incidence rates of gastric cardia and esophageal adenocarcinomas are increasing, but data suggest that carriage cagA(+) Helicobacter pylori strains may protect against development Barrett's esophagus adenocarcinoma. Our aims were to examine the relationship between pre-malignant malignant lesions in serum antibodies H. antigens patients with without complications esophagus. prevalence carditis was 40% controls compared 13% complicated or uncomplicated adenocarcinoma (p < 0.001). Cardia intestinal metaplasia (IM) atrophy present concordant 28% less frequent alone dysplasia/adenocarcinoma (0% for each, p Carriage 34% significantly associated increased frequency severity inflammation, IM, not IgA HspA seropositivity pylori-colonized persons normal histology
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