Renewal of Mural Thrombus Releases Plasma Markers and Is Involved in Aortic Abdominal Aneurysm Evolution

摘要: Human abdominal aortic aneurysm (AAA) expansion has been linked to the presence of a mural thrombus. Here we explored mechanism continual luminal renewal this thrombus and its ability release biological markers potentially detectable in plasma. We also platelet inhibition pacify limit progression an experimental model. Blood samples thrombi were collected 20 AAA patients. In parallel, segments sodium dodecyl sulfate-decellularized guinea pig aorta xenografted onto 30 rats induce aneurysms. Fifteen received abciximab treatment fifteen irrelevant immunoglobulins. Procoagulant activity activation (microparticles, sP-selectin, sGPV, sCD40L) increased threefold fivefold eluates from layer compared other layers. All these twofold patients' plasma matched controls (P < 0.005). rat model, reduced both area aneurysmal enlargement 0.05). Platelet aggregation is probably responsible for AAA. The released that could easily be detected limited providing new therapeutic perspectives prevention enlargement.