Rationale for monitoring cyclosporine concentration at 2 hours after administration in infants posttransplantation.

摘要: Therapeutic drug monitoring is critical to avoid overimmunosuppression or underimmunosuppression in young pediatric transplant recipients. The objective of this study was examine cyclosporine (CsA) trough (C0) and 2-hour post-dose (C2) concentrations the early period after liver transplantation (OLT) determine whether CsA C2 justified. Seventeen infants younger than 2 years treated with (Neoral) were monitored at C0. biopsy-proved acute rejection rate 65% 3 months post-OLT. No correlation observed between values C0 C2. Poor absorption most during first weeks post-OLT, as well interindividual variability clearance. Exposure could not be estimated using either determinations post-OLT period. As a marker poor absorption, useful but does indicate delayed rapid clearance without simultaneous measurement concentration We suggest use both monitoring, AUC on an individual basis least