Small-bowel length and the dose of cyclosporine in children after liver transplantation.

摘要: Children, particularly infants, require large oral doses of cyclosporine to achieve immunosuppression after liver transplantation. In 53 children who had received transplants, we examined the relation height, weight, residual small-bowel length, and (in 17 children) terminal plasma clearance rate dose required blood levels 200 ng per milliliter. The intravenous (expressed as milligrams day) increased steeply body size bowel length increased, whereas declined with increasing length. When expressed square meter body-surface area day, did not change size, but size. Small-bowel correlated closely inversely log (r = -0.77, P 0.0001). was also related 0.57, 0.017) independent age Multiple regression analyses that included height weight showed only from were independently cyclosporine. We concluded small is chief determinant orally administered in Children infants because limited absorptive surface their intestines.