Studies on the Physiological Role of Brain-Derived Neurotrophic Factor and neurotrophin-3 in Knockout Mice
作者： R. Jaenisch , P. Ernfors , J. Loring , Kuo-Fen Lee , J. Kucera
DOI: 10.1387/IJDB.8645564
关键词:
摘要: Brain-derived neurotrophic factor and neurotrophin-3 deficient mice were generated by gene targeting. The analysis of these has led to the characterization their role in survival neurons peripheral nervous system. NT-3 displayed severe movement defects most died shortly after birth. mutation causes loss substantial portions cranial spinal sensory sympathetic neurons. Significantly, proprioceptive afferents sense organs (muscle spindles Golgi tendon organs) completely absent homozygous mutant mice. BDNF deficiencies coordination balance. Excessive was detected ganglia examined, but not affected. marked reduction observed vestibular ganglion, leading a innervation epithelia compartments inner ear.
sci-hub.se 参考文章(81)
C. Kalcheim, Y. A. Barde, H. Thoenen, N. M. Le Douarin, In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells. The EMBO Journal. ,vol. 6, pp. 2871- 2873 ,(1987) , 10.1002/J.1460-2075.1987.TB02589.X
H. Persson, P. Ernfors, C. F. Ibañez, F. Hallböök, W. J. Friedman, J.-P. Merlio, O. Lindvall, J. Bengzon, N. Lindefors, T. Ebendal, L. Olson, Neurotrophins and their Receptors Springer, Berlin, Heidelberg. pp. 180- 200 ,(1992) , 10.1007/978-3-642-84842-1_15
A Sutter, R J Riopelle, R M Harris-Warrick, E M Shooter, Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. Journal of Biological Chemistry. ,vol. 254, pp. 5972- 5982 ,(1979) , 10.1016/S0021-9258(18)50507-X
Y.A. Barde, D. Edgar, H. Thoenen, Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal. ,vol. 1, pp. 549- 553 ,(1982) , 10.1002/J.1460-2075.1982.TB01207.X
PM Richardson, VM Issa, RJ Riopelle, None, Distribution of neuronal receptors for nerve growth factor in the rat The Journal of Neuroscience. ,vol. 6, pp. 2312- 2321 ,(1986) , 10.1523/JNEUROSCI.06-08-02312.1986
A. Rodríguez-Tébar, G. Dechant, R. Götz, Y.A. Barde, Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. The EMBO Journal. ,vol. 11, pp. 917- 922 ,(1992) , 10.1002/J.1460-2075.1992.TB05130.X
A Rodriguez-Tebar, YA Barde, Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo The Journal of Neuroscience. ,vol. 8, pp. 3337- 3342 ,(1988) , 10.1523/JNEUROSCI.08-09-03337.1988
F. Hallbook, H. Persson, T. Ebendal, C. Ayer-Lelievre, Expression of nerve growth factor receptor mRNA during early development of the chicken embryo: emphasis on cranial ganglia. Development. ,vol. 108, pp. 693- 704 ,(1990)
X Mu, I Silos-Santiago, SL Carroll, WD Snider, Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia The Journal of Neuroscience. ,vol. 13, pp. 4029- 4041 ,(1993) , 10.1523/JNEUROSCI.13-09-04029.1993
U. Pirvola, J. Ylikoski, J. Palgi, E. Lehtonen, U. Arumae, M. Saarma, Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 9915- 9919 ,(1992) , 10.1073/PNAS.89.20.9915