Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome.

摘要: Objective. To address the clinical, serologic, pathologic, and immunogenetic features of sicca syndrome that occurs in systemic lupus erythematosus (SLE), as well its similarities to, differences from, primary Sjogren's (SS). Methods. A cohort 283 consecutive unselected SLE patients was evaluated for presence associated SS using American–European classification criteria. Clinical laboratory parameters with (SLE–SS) were compared those without (SLE–no SS) a group 86 SS. Results. SS identified 26 (9.2%); preceded development 18 them (69.2%). Compared SLE–no group, SLE–SS significantly older, had higher frequency Raynaud's phenomenon, anti-Ro/SSA, anti-La/SSB, rheumatoid factor, but lower renal involvement, lymphadenopathy, thrombocytopenia. displayed clinically similar syndrome, younger an increased perivascular infiltrates salivary glands anticardiolipin antibodies serum. high DRB1*0301 allele. This HLA profile distinguished from who DRB1*1501 DQB1*0602 alleles, to DRB1*0301. Conclusion. SLE–SS appears constitute subgroup distinct features, whom is expressed overlapping entity largely SS.