Bis Expression in Patients with Surgically Resected Lung Cancer and its Clinical Significance

摘要: Bis, also known as BAG3, has been identified a Bcl-2-interacting protein that enhances cellular anti-apoptotic activity. It is involved in differentiation, angiogenesis, migration, and invasion various tumors. The purpose of this study was to investigate the Bis expression pattern, clinical significance thereof, patients with resected lung cancer. We studied 121 cancer who underwent curative surgical resection. Patient clinicopathological characteristics were reviewed retrospectively from medical records, including tumor recurrence survival. tissues evaluated by immunohistochemical staining assessed using four-tiered intensity score system (negative, weak, moderate, strong). Enhanced at periphery facing adjacent nontumor region referred “marginal activity.” Although higher squamous cell carcinoma than adenocarcinoma, marginal activity adenocarcinoma carcinoma. All small carcinomas neuroendocrine differentiation examined negative for expression. Compared stage I cancer, II IIIA exhibited levels tissues. Recurrence survival rates did not differ significantly according or Our demonstrated differed histological type pathological Further studies are needed assess its use biomarker role molecular pathogenesis