Glucocorticoid receptor content of T lymphocytes: evidence for heterogeneity.

摘要: Glucocorticoid receptors were measured in T lymphocytes that isolated from peripheral blood by either nylon wool filtration or E-rosette sedimentation. cells specifically bind 6.7 +/- 0.2 fmol of dexamethasone per million (equivalent to 4000 200 cell), whereas sedimentation 12.0 0.7 7200 400 cell). This difference the amount bound two cell preparations was significant (p less than .001) and present immediately after isolation. The binding affinities different for similar. are a combination followed same as alone. following do These findings suggest heterogeneous with respect their quantity glucocorticoid receptors. Isolation enriches have greater number receptors, isolation lesser