The sensitivity of peripheral blood lymphocytes to growth inhibition by hydrocortisone is not determined by their OKT4:OKT8 ratio
作者： Christa Roberts , R.C. Potts , R.A. Brown , J.H. Gibbs , Margaret C.K. Browning
DOI: 10.1016/0165-2478(83)90009-3
关键词: Peripheral blood 、 Endocrinology 、 Hydrocortisone 、 Lymphocyte 、 Glucocorticoid 、 Growth inhibition 、 Monoclonal antibody 、 Cell cycle 、 Internal medicine 、 Biology 、 Phytohemagglutinins
摘要: Normal adult human subjects show considerable variation in sensitivity to depression of the activation phase mitogen-induced lymphocyte growth by natural glucocorticoid, hydrocortisone. In a study 21 subjects, slope log-dose response hydrocortisone was unrelated relative numbers cells two major T-cell subpopulations stained OKT4 and OKT8 monoclonal antibodies. It is concluded that extent glucocorticoid-induced suppression early mitogen-stimulated probably not determined various immunoregulatory lymphocytes.
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