Reduction of endoplasmic reticulum stress—A novel mechanism of action of statins in the protection against atherosclerosis
作者： Ikaro Breder , Andressa Coope , Ana Paula Arruda , Daniela Razolli , Marciane Milanski
DOI: 10.1016/J.ATHEROSCLEROSIS.2010.04.036
关键词:
摘要: Fatty-acid-induced endoplasmic reticulum stress has been recently described as a novel mechanism involved in the genesis of atherosclerosis. Here we show that statins, class drug widely employed clinical management hypercholesterolemia, reduces lipid-induced macrophage an isolated cell system and LDL receptor knockout mice. Given importance inducer inflammation, suspect action herein for statins may play major role on its beneficial effects prevention cardiovascular disease.
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