HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

摘要: The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial. aim the study was to asses status, its correlations with clinicopathological parameters, and impact GC patients. Tumor samples were collected from 78 patients who had undergone curative surgery. In order evaluate intensity immunohistochemical (IHC) reactions two scales applied: immunoreactive score according Remmele modified by authors standardised Hercep test for Hofmann et al. overexpression detected IHC 23 (29.5%) tumors (score 2+/3+) 24 (30.7%) IRS scale (IRS 4-12). associated poorly differentiated tumors, but this correlation not significant (P = 0.064). No relationship found between primary tumor size degree spread regional lymph nodes. Both univariate multivariate analyses revealed that TNM stage patient's age crucial negative factors. observed patient survival estimated using both scales. This research did confirm (evaluated immunohistochemistry) value tool GC.