Overexpression of Her-2 upregulates FoxM1 in gastric cancer.

摘要: The transcription factor, forkhead box protein M1 (FoxM1), and the tyrosine kinase receptor, human epidermal growth factor receptor-2 (Her-2), are aberrantly expressed in a number of malignancies, closely associated with development cancer. However, their regulatory mechanisms involvement tumor have not been extensively investigated, particularly gastric In present study, we examined expression levels FoxM1 Her-2 samples from patients cancer, as well cancer cell lines. Their connection between them were also explored. We found that was markedly higher samples, while strong association at mRNA level. When regulated lines, changed accordingly. Following transfection vectors into luciferase activity promoter positively increased along concentration pcDNA3.1-Her-2. Her-2-siRNA inverted this variation, which further confirmed by treatment inhibitor, trastuzumab, revealing regulates level cells. Our results suggest important diagnostic markers for may be potential cellular target therapeutic intervention, cancers resistant to Her-2-targeted therapy.