L-Methionine based phenolic compound mediates unusual assembly of AgNPs and exerts efficient anti-biofilm effect

摘要: 2-(2-Hydroxybenzylamino)-4-(methylthio)butanoic acid (L) together with capping molecules, produced AgNPs unusual nanostructures that showed efficient inhibition of biofilm growth. Nanoplates self-assemble into micron sized flower-petal like structures in L–PSS–AgNPs whereas mesocrystals visible voids from smaller nanoplates formed L–SDS–AgNPs. L–PVA– and L–PVP–AgNPs polydispersed multi-shaped nanoparticles including nanoprisms, spheres plates. Structure–property studies indicate slow reduction Ag+ ions thiophilic interaction L is responsible for the morphology organization AgNPs. Importantly L-capping molecules–AgNPs exhibited strong inhibitory effect against four different bacteria, S. aureus, P. aeruginosa, B. subtilis E. coli which, former two are classical colonizers burn wounds. BIC (biofilm concentration) MIC (minimum further confirmed true anti-biofilm Studies to unravel mechanism action indicated enhanced could be attributed altered membrane permeability integrity caused by L, which turn curtails bacterial colonization as revealed confocal imaging. Thus a simple amino modified phenolic molecule an interesting assembly remarkable activity, holds promise its potential use fabrication wound healing dressing materials.