Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression.

摘要: Background. Cyclosporine and tacrolimus are associated with drug-induced renal dysfunction that may exacerbate recovery from ischemic injuries during the first month posttransplant. We sought to use anti-CD25 (anti-interleukin-2 receptor) monoclonal antibodies in combination sirolimus (rapamycin) avoid cyclosporine therapy early postoperative period six transplant recipients deemed be at high risk for delayed graft function. Methods. Six consecutive patients function were treated rapamycin (2-12 mg/day), antibodies, steroids, withholding inception of until serum creatinine fell below 3.0 mg/dl. Results. During 2 months posttransplant, none displayed clinical or histopathological evidence acute allograft rejection episodes, cytokine release syndrome, hypersensitivity reactions. None received even empiric bolus high-dose steroid a presumed episode. All recovered within 8 weeks To date all have stable Five levels between 0.8 1.3 mg/dl 6 other patient has level 1.7 present follow-up Conclusion. posttransplant combined steroids offer promising baseline exposure facilitate ischemic/reperfusion injuries.