Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases.

摘要: Background Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepidermal blistering disease of dogs, cats and humans. Objectives The goal this study was to describe the clinical, histological immunological features treatment outcomes canine MMP. Animals Sixteen dogs were diagnosed with MMP based on presence mucosal- or mucocutaneous-predominant vesiculation and/or ulceration, confirmation clefting an age onset greater than 6 months. Results Six 16 (38%) German shepherd their crosses. The median 6 years (range: 1–10 years). At time presentation, exhibited erosions ulcers in oral cavity (11 16; 69%), nasal (nine 56%), periocular (eight 50%) genital (six 38%) regions. Haired skin lesions less frequent involved mostly concave pinnae. Information outcome available for 11 (69%). A complete remission (CR) achieved 10 (91%). CR 33 weeks 6–64 weeks). Treatment regimens varied widely but six (60%) received combination tetracycline antibiotic niacinamide alone, another drug, at CR. Forty percent which had occurred experienced lesion relapse upon drug dose reduction. Conclusions clinical importance Canine relapsing requiring long term treatment. Combination therapy often needed achieve