Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases.

摘要: Background Epidermolysis bullosa acquisita (EBA) is a rare autoimmune subepidermal blistering disease of dogs and humans. Objectives Our objectives were to describe clinical phenotypes, histopathology treatment outcomes canine EBA. Animals Twenty diagnosed with EBA based on blister formation collagen VII autoreactivity. Results Most young (median: 1.2-year-old) male-to-female ratio 2.3:1. Nine 20 (45%) developed lesions before one year age 11 (55%) great danes. Tense vesicles bullae (18 20; 90%) deep erosions ulcers (20 100%) the most common these affected predominantly oral cavity (19 95%), pinnae (16 80%), axillae (15 75%) footpads (14 70%). Histopathology identified neutrophilic perivascular dermatitis (17 17; without or (12 71%) eosinophils, which occasionally equalled (four cases) outnumbered neutrophils (two cases). Subepidermal either devoid inflammation contained fibrin and/or haemorrhage. A complete remission skin was obtained in 14 median time 58 days. Glucocorticoids used as monotherapy (3 14; 21%) combination other immunomodulating drugs (11 79%). The dose prednisone 3 mg/kg/day. remaining six euthanized. Conclusions importance Canine an inflammatory phenotype predilection for danes male dogs. outcome appears more favourable than assumed previously.