Volumetric and MGMT parameters in glioblastoma patients: survival analysis.

摘要: In this study several tumor-related volumes were assessed by means of a computer-based application and survival analysis was conducted to evaluate the prognostic significance pre- postoperative volumetric data in patients harboring glioblastomas. addition, MGMT (O6-methylguanine methyltransferase) related parameters compared with those volumetry order observe possible relevance molecule tumor development. We prospectively analyzed 65 suffering from glioblastoma (GBM) who underwent radiotherapy concomitant adjuvant temozolomide. For purpose T1 T2-weighted magnetic resonance (MR) sequences used, acquired both postoperatively (pre-radiochemotherapy). The measured on preoperative MR images necrosis, enhancing edema (including tumor) ones, net-enhancing tumor. Age, sex, performance status (PS) type operation also included multivariate analysis. for promoter methylation Multiplex Ligation-dependent Probe Amplification (MLPA), RNA expression real time PCR, protein immunohistochemistry total 44 cases available histologic material. negative impact shown pre-radiochemotherapy overall (OS) (p = 0.023) necrosis progression-free (PFS) 0.030). Furthermore, confirmed importance PS PFS OS patients. observed 13/23 (43.5%) evaluable tumors; complete 3/13 methylated tumors only. High rate positivity (> 20% positive neoplastic nuclei) inversely associated pre-operative 0.021). Our findings implicate that may have significant role prognosis GBM could help not only improve prediction outcome but itself identifying at high risk treatment failure and, thus, seek alternative these small series, less aggressive characteristics.