A population-based study of high-grade gliomas and mutated isocitrate dehydrogenase 1
作者： Rikke H Dahlrot , Jørn Herrstedt , Bjarne W Kristensen , Jacob Hjelmborg , Steinbjørn Hansen
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摘要: High-grade gliomas have a dismal prognosis, and prognostic factors are needed to optimize treatment algorithms. In this study we identified clinical as well the value of isocitrate dehydrogenase 1 (IDH1) status in population-based group patients with high-grade gliomas. Using Danish Cancer Registry Pathology Databank 359 patients: 234 had WHO grade IV gliomas, 58 III 67 were diagnosed clinically. Mutated IDH1 was predominantly observed oligodendroglial tumors (WHO III). Patients mutated significantly better outcome than wildtype IDH1: 2-year OS 59% 18%, respectively (HR 0.38, 95% CI 0.21-0.68). However, when adjusting for other factors, not significant independent factor (HR=0.58, 0.32-1.07). Young age, absence neurological deficit, performance 0–1, tumor crossing midline, receiving post-surgical indicators good prognosis multivariate analysis. conclusion: This could demonstrate be an effect classic factors.
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