High levels of c-Met is associated with poor prognosis in glioblastoma.

摘要: The tyrosine kinase receptor c-Met has been suggested to be involved in crucial parts of glioma biology like tumor stemness, growth and invasion. aim this study was investigate the prognostic value a population-based patient cohort. Tissue samples from 238 patients with WHO grade I, II, III IV tumors were analyzed using immunohistochemical staining advanced image analysis. Strong expression found cells, blood vessels, peri-necrotic areas. At subcellular level, identified cytoplasm cell membrane. Measurements high intensity correlated (p = 0.006) but no association survival observed II (p = 0.09) or (p = 0.17) tumors. High associated shorter overall glioblastoma multiforme (p = 0.03). However effect glioblastomas time-dependent only who survived more than 8.5 months, not within first 8.5 months after diagnosis. This significant multivariate analysis (HR 1.99, 95 % CI 1.29–3.08, p = 0.002) adjusted for treatment clinical variables age 1.01, 0.99–1.03, p = 0.30), performance status 1.34, 1.17–1.53, p < 0.001), and tumor crossing midline 1.28, 0.79–2.07, p = 0.29). In conclusion, showed that levels holds unfavorable glioblastomas.