Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo.

作者: N. S. Hou , A. Gutschmidt , D. Y. Choi , K. Pather , X. Shi

DOI: 10.1073/PNAS.1318262111

关键词:

摘要: … Our investigation thus offers an alternate perspective on how lipid disequilibrium induces the UPR ER , because we observe activated UPR ER without evidence of severely disturbed …

参考文章(55)
Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. ,vol. 391, pp. 806- 811 ,(1998) , 10.1038/35888
David Collar, Vida Praitis, Elizabeth Casey, Judith Austin, Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics. ,vol. 157, pp. 1217- 1226 ,(2001) , 10.1093/GENETICS/157.3.1217
S Brenner, THE GENETICS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 77, pp. 71- 94 ,(1974) , 10.1093/GENETICS/77.1.71
Rick Morimoto, David M. Kurnit, Kazutoshi Mori, Randal J. Kaufman, Xiaohua Shen, Ronald E. Ellis, Kyungho Lee, Chuan-Yin Liu, Kun Yang, Aaron Solomon, Hiderou Yoshida, Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development Cell. ,vol. 107, pp. 893- 903 ,(2001) , 10.1016/S0092-8674(01)00612-2
Julie Deguil, Ludovic Pineau, Ellen Claire Rowland Snyder, Sébastien Dupont, Laurent Beney, Adrià Gil, Gilles Frapper, Thierry Ferreira, Modulation of Lipid-Induced ER Stress by Fatty Acid Shape Traffic. ,vol. 12, pp. 349- 362 ,(2011) , 10.1111/J.1600-0854.2010.01150.X
Miriam Cnop, Laurence Ladriere, Paul Hekerman, Fernanda Ortis, Alessandra K. Cardozo, Zeynep Dogusan, Daisy Flamez, Michael Boyce, Junying Yuan, Decio L. Eizirik, Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis Journal of Biological Chemistry. ,vol. 282, pp. 3989- 3997 ,(2006) , 10.1074/JBC.M607627200
Ronald C Conaway, Joan Weliky Conaway, Function and regulation of the Mediator complex Current Opinion in Genetics & Development. ,vol. 21, pp. 225- 230 ,(2011) , 10.1016/J.GDE.2011.01.013
Nicole Shangming Hou, Stefan Taubert, Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging. Frontiers in Physiology. ,vol. 3, pp. 143- 143 ,(2012) , 10.3389/FPHYS.2012.00143
Fajun Yang, Bryan W. Vought, John S. Satterlee, Amy K. Walker, Z.-Y. Jim Sun, Jennifer L. Watts, Rosalie DeBeaumont, R. Mako Saito, Sven G. Hyberts, Shaosong Yang, Christine Macol, Lakshmanan Iyer, Robert Tjian, Sander van den Heuvel, Anne C. Hart, Gerhard Wagner, Anders M. Näär, An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis Nature. ,vol. 442, pp. 700- 704 ,(2006) , 10.1038/NATURE04942
Sohail Malik, Robert G. Roeder, The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation Nature Reviews Genetics. ,vol. 11, pp. 761- 772 ,(2010) , 10.1038/NRG2901