Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides
作者： Adam M. Pieczonka , Aleksandra Strzelczyk , Beata Sadowska , Grzegorz Mlostoń , Paweł Stączek
DOI: 10.1016/J.EJMECH.2013.04.023
关键词:
摘要: In this work we reported the synthesis and evaluation of in vitro antimicrobial activities hydrazones 6 obtained from 3-oxido-1H-imidazole-4-carbohydrazides 4. All new compounds were characterized by spectroscopic methods. Hydrazones tested for their activity against four Gram-positive Gram-negative strains bacteria as well one fungal species. Three appeared to be promising agents reference Escherichia coli, Staphylococcus aureus epidermidis. They also twelve clinical isolates S. cytotoxic effect on murine fibroblasts HeLa human tumor cell line was determined.
elsevier.com
sci-hub.se 参考文章(41)
YOSHIHISA MIZUNO, TAKESHI ENDO, YASUKO INOUE, HAJIME TAMPO, AKIRA TAKAHASHI, MASAAKI IIGO, AKIO HOSHI, KAZUO KURETANI, Studies on the chemical synthesis of potential antimetabolites. XXIV. The synthesis and antitumor activities of p-tosylhydrazones of 2-formylpyridine 1-oxides and 2-formylazoles 3-oxides. Chemical & Pharmaceutical Bulletin. ,vol. 28, pp. 1584- 1589 ,(1980) , 10.1248/CPB.28.1584
Shawna F. Graves, Scott D. Kobayashi, Frank R. DeLeo, Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence. Journal of Molecular Medicine. ,vol. 88, pp. 109- 114 ,(2010) , 10.1007/S00109-009-0573-X
André P. Liesen, Thiago M. de Aquino, Cristiane S. Carvalho, Vânia T. Lima, Janete M. de Araújo, José G. de Lima, Antônio R. de Faria, Edésio J.T. de Melo, Antonio J. Alves, Elias W. Alves, Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles. European Journal of Medicinal Chemistry. ,vol. 45, pp. 3685- 3691 ,(2010) , 10.1016/J.EJMECH.2010.05.017
Luisa Savini, Luisa Chiasserini, Cesare Pellerano, Walter Filippelli, Giuseppe Falcone, Synthesis and pharmacological activity of 1,2,4-triazolo[4,3-a]quinolines. Farmaco. ,vol. 56, pp. 939- 945 ,(2001) , 10.1016/S0014-827X(01)01166-1
Yun Wang, Joshua P. Gray, Vladimir Mishin, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin, Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity Free Radical Biology and Medicine. ,vol. 44, pp. 1169- 1179 ,(2008) , 10.1016/J.FREERADBIOMED.2007.12.013
Juliana M Figueiredo, Celso de A Câmara, Emanuel G Amarante, Ana Luisa P Miranda, Fúlvia M Santos, Carlos R Rodrigues, Carlos Alberto M Fraga, Eliezer J Barreiro, None, Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylhydrazone Derivatives Bioorganic & Medicinal Chemistry. ,vol. 8, pp. 2243- 2248 ,(2000) , 10.1016/S0968-0896(00)00152-8
Birsen Tozkoparan, Esra Küpeli, Erdem Yeşilada, Mevlüt Ertan, Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory–analgesic activity Bioorganic & Medicinal Chemistry. ,vol. 15, pp. 1808- 1814 ,(2007) , 10.1016/J.BMC.2006.11.029
Vandana Jugran Negi, Biological Activities of Hydrazone Derivatives in the New Millennium International Journal of Pharmaceutical Chemistry. ,vol. 2, pp. 100- 109 ,(2013) , 10.7439/IJPC.V2I4.516
Gabriela Aguirre, Mariana Boiani, Hugo Cerecetto, Alejandra Gerpe, Mercedes González, Yolanda Fernández Sainz, Ana Denicola, Carmen Ochoa de Ocáriz, Juan José Nogal, David Montero, José Antonio Escario, Novel Antiprotozoal Products: Imidazole and Benzimidazole N‐Oxide Derivatives and Related Compounds Archiv Der Pharmazie. ,vol. 337, pp. 259- 270 ,(2004) , 10.1002/ARDP.200300840
Beata Sadowska, Barbara Rózalska, Marzena Wieckowska-Szakiel, Staphylokinase production by clinical Staphylococcus aureus strains. Polish Journal of Microbiology. ,vol. 56, pp. 97- 102 ,(2007)