Novel Antiprotozoal Products: Imidazole and Benzimidazole N‐Oxide Derivatives and Related Compounds

摘要: The syntheses and biological evaluation of the first anti-protozoa imidazole N-oxide benzimidazole their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi Trichomonas vaginalis. Derivative 7c, ethyl-1-(i-butyloxycarbonyloxy)-6-nitrobenzimid-azole-2-carboxylate, displayed activity on both protozoa. Lipophilicity redox potential experimentally determined order to study relationship with compounds. These properties well related observed bioactivity. Imidazole becoming leaders for further chemical modifications advanced studies.