Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia.

摘要: Object. Insulin has been shown to ameliorate cerebral necrosis in global and, more recently, focal ischemia. The goal of this study was determine the relationship between neuroprotective effect and blood sugar levels a rat model Methods. Thirty-four rats were subjected 80 minutes transient middle artery occlusion at mean arterial pressure 60 mm Hg temperature 37˚C. (3.5 IU/kg) administered 1 hour before (12 rats) 20 after ischemia; 10 animals served as controls. A quantitative histopathological conducted week survival showed that insulin not beneficial reducing size infarction or selective neuronal penumbra when In addition infarction, six from insulintreated groups had bilateral hippocampus neocortex. nonlinear regression analysis which glucose compared with both cortical total yielded U-shaped curve nadir for lay 6- 7-mM range. increased brain damage induced by occurred very low values range 2 3 mM. Conclusions. These results indicate if is used following ischemia, should be maintained approximately 6 7 From these data one can infer hypoglycemia less than mM avoided situations ischemia used. Additional animal studies clinical trials humans are needed effects on