Acute and chronic effects of self-expanding nitinol stents in porcine coronary arteries.

摘要: BACKGROUND There is a paucity of experimental data regarding self-expanding stents. This study evaluated the acute and chronic effects CardioCoil, nitinol coil stent, in porcine coronary arteries. METHODS Twenty-three stents were implanted without associated balloon angioplasty normal arteries 12 pigs, which serially sacrificed up to 6 months. Angiographic histologic analyses performed evaluate deployment characteristics, patency rates, neointimal response, unique features nature CardioCoil stent. RESULTS All successfully deployed remained patent acutely. Three undersized migrated proximally there was one episode subacute thrombosis an oversized The remaining throughout survival period responses favorable for months (all mean neointima < 200 microns months). evidence continuing stent expansion over time (stent diameter 2.85 +/- 0.78 mm immediately after 3.24 0.97 at follow-up) majority struts adventitia by Re-endothelization occurred starting week implantation complete 8 weeks. CONCLUSIONS shows that with characteristics although appropriate sizing more crucial than balloon-expandable More importantly, appears be "dissociation' between deep vessel wall injury strut process reaction, unlike