HIF-mediated innate immune responses: cell signaling and therapeutic implications.

摘要: Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs) are key mediators of cellular responses hypoxia and, as other cell types, HIFs critical for upregulation glycolysis, which enables innate cells produce adenosine triphosphate anaerobically. An increasing body evidence demonstrates that also regulates many immunological functions, including migration, apoptosis, phagocytosis pathogens, antigen presentation and production cytokines, chemokines, angiogenic antimicrobial factors. Many these functions mediated by HIFs, not only stabilized posttranslationally hypoxia, but transcriptionally upregulated inflammatory signals. Here, we review role both vitro vivo, with a particular focus on myeloid cells, majority studies have so far been carried out.