Effect of glutamine on the intestinal permeability changes induced by indomethacin in humans

摘要: Background : Long-term non-steroidal anti-inflammatory drug (NSAID) intake may induce increased intestinal permeability, eventually resulting in enteropathy. Because permeability might be related to cell damage from energy depletion, it was hypothesized that glutamine—the major source of the mucosal cell—might prevent changes. Methods : The 6-h urinary excretion 51Cr-EDTA after an oral load used this study as a measure for permeability. Healthy volunteers underwent series tests: (i) basal test; (ii) test following NSAID (indomethacin); (iii) combination with glutamine and/or misoprostol. Results : induced all volunteers. Pre-treatment (3 × 7 g daily, 1 week before NSAID-dosing) did not NSAID-induced increase Multiple doses close time NSAID-dosing resulted significantly lower compared without glutamine. Co-administration misoprostol multiple-dose scheme further reduction permeability. Conclusions : Glutamine decreases changes caused by when is administered time, and has synergistic effect.