Comparison of Cefepime-Cefpirome and Carbapenem Therapy for Acinetobacter Bloodstream Infection in a Multicenter Study.

摘要: Carbapenems are currently the preferred agents for treatment of serious Acinetobacter infections. However, whether cefepime-cefpirome can be used to treat an bloodstream infection (BSI) if it is active against causative pathogen(s) not clear. This study aimed compare efficacy and carbapenem monotherapy in patients with BSI. The population included 360 monomicrobial BSI receiving appropriate antimicrobial therapy admitted four medical centers Taiwan 2012 2017. predictors 30-day mortality were determined by Cox regression analysis. overall rate antibiotic group was 25.0% (90/360 patients). crude rates 11.5% (7/61 patients) 26.3% (21/80 patients), respectively. or infected nosocomialis (51.8%), baumannii (18.4%), pittii (12.1%). After adjusting age, Sequential Organ Failure Assessment (SOFA) score, invasive procedures, underlying diseases, independently associated a higher lower compared that therapy. SOFA score (hazard ratio [HR], 1.324; 95% confidence interval [CI], 1.137 1.543; P < 0.001) neutropenia (HR, 7.060; CI, 1.607 31.019; = 0.010) independent risk factors monotherapy. incidence densities versus 0.40% 1.04%, therapeutic response comparable carbapenems among