Optimal Two-Stage Testing for Family-Based Genome-wide Association Studies
作者： Stuart Macgregor
DOI: 10.1016/J.AJHG.2008.02.003
关键词:
摘要: In R, the power of “total” test with parameters given above iswhere pchisq and qchisq are distribution quantile function, respectively, χ12 distribution. The qchisq(0.05/100000,1,lower.tail = FALSE) part gives critical value to be evaluated against noncentral function for a NCP. “screening” isIf both proportion markers information coming from “between” “within” stages varied across full range possible values (by, example, use two nested loops in R), approach is always lower than approach.
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