Relationship between bronchial hyperresponsiveness and lung function in children age 5 and 6 with and without asthma

摘要: Background and objective It is unknown whether wheezy children have bronchial hyperresponsiveness (BHR) or which lung function parameters are correlated with BHR in children. We evaluated the relationship between functions by minimizing effects of age height asthmatic, non-asthmatic wheezers healthy children. Methods The subjects comprised 154 aged 5 6 years (78 males, 76 females), who were divided into three groups: asthmatics, controls. Spirometry a methacholine inhalation challenge oscillation method performed. Results The study cohort was 5.9 ± 0.2 (mean ± standard deviation), 114.4 ± 5.3 cm. No significant differences height, weight, body mass index observed groups. The minimal dose to start bronchoconstriction, parameter sensitivity, lower asthmatics than that speed bronchoconstriction response methacholine, reactivity, strongly baseline respiratory resistance (Rrs cont) all groups. Conclusions Our data suggest it not possible distinguish preschool asthma from based on their sensitivity Rrs has strong effect reactivity