Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View
作者： M. Solimena , R. Dirkx , M. Butler , J.-M. Hermel , J. Guernaccia
DOI: 10.1007/978-3-0348-8990-2_5
关键词:
摘要: Evidence collected during the last decade suggests that Stiff-Man syndrome (SMS), a neuromuscular disorder characterized by continuous rigidity of body musculature, results from an autoimmune impairment inhibitory neurons controlling motor neuron activity. The dominant autoantigen is glutamic acid decarboxylase (GAD), enzyme responsible for synthesis GABA. In this chapter, we summarize some relevant features SMS and GAD, with emphasis on contribution our group to field.
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