T-cell subpopulations, expression of interleukin-2 receptor, and production of interleukin-2 and gamma interferon in human American cutaneous leishmaniasis.

摘要: Leukocyte subpopulations, the expression of interleukin-2 (IL-2) receptor, and production IL-2 gamma interferon (IFN-gamma) were studied in peripheral blood mononuclear cells American cutaneous leishmaniasis patients that had been stimulated vitro with either leishmanial antigen or mitogen (phytohemagglutinin M). The 75 examined classified as having localized (LCL; 66 patients), mucocutaneous (MCL; 5 rare diffuse (DCL; 4 patients) form disease. Patients DCL, who are characterized by their defective cell-mediated immune response to antigen, failed express receptor did not produce IFN-gamma when exposed but so phytohemagglutinin M. Both LCL MCL showed strong proliferative responses antigen; these far greatest patients. groups significantly increased after exposure mitogen, highest Concerning leukocyte subpopulations evaluated (CD2, CD4, CD8, CD20, MO2), most significant findings a decrease both CD4+ CD4/CD8 ratio compared other groups. Considering production, M amounts comparable those controls. Our results help explain anergy T from DCL which could lead possibly contribute incapacity kill Leishmania parasite. patients, decreased CD4 (helper-inducer suppression) phenotype, elevated IFV-gamma might partially explains state hypersensitivity mucosal damage exhibited