Immunogenetics of human american Cutaneous Leishmaniasis: Study of HLA haplotypes in 24 families from Venezuela

摘要: Abstract Twenty-four families with one or multiple cases of localized cutaneous leishmaniasis (LCL) from an endemic region the highest incidence LCL in Venezuela were typed HLA-ABC, DR, DQ antigens and complement factors. The parental HLA haplotypes segregated at random among healthy affected siblings but backcross significantly higher frequencies HLA-A28 (p = 0.0018), -Bw22 0.0122), -DQw8 0.0364) present compared to siblings. HLA-B15 showed a frequency 0.0062) latter group. Haplotypes Bw22CF31 0.0076) Bw22DRw11DQw7 0.0163) also more frequent A2Cw_ 0.0445) latter. No genetic linkage putative susceptibility gene(s) could be demonstrated this study. A case/control comparison 26 unrelated patients (one proband each family) individuals same ethnic origin confirmed association HLA-Bw22 (pc 0.048) -DQw3 0.036) LCL. relative risk reached 12.5 for Bw22 4.25 DQw3 ethiologic factors 0.17 0.64, respectively. HLA-DQw3 apparently makes major contribution as factor population level.