Concentrations of copper and zinc in liver and serum samples in biliary atresia patients at different stages of traditional surgeries.

摘要: Many patients with biliary atresia (BA) have impaired metabolism of copper (Cu) and zinc (Zn) because the obstruction bile ducts. An excessive Cu accumulation is cytotoxic results in fibrosis hepatic tissues. Since Zn works antagonistically to Cu, lower concentrations may deteriorate liver damage. In 1980's, we performed a series surgeries on BA for construction alteration flow route, which major excretion route Cu. We obtained serum samples at each surgery, measured by inductively coupled plasma atomic emission spectrometry. Hepatic concentration decreased improvement cholestasis after establishment excretion. Conversely, when persisted or recurred, increases were noted. was than previously reported normal values. High due persistent recurrent low cirrhosis.