Amphotericin B Serum Concentrations During Therapy 1

摘要: Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations this drug that are produced in these patients. Because current data conflicting, magnitude was restudied by using a bioassay which gave precise and accurate results. The highest 155 2.01 μg/ml. Mean were 1.21, 0.62, 0.32 μg/ml, at 1, 18, 42 hr, respectively, after intravenous infusion B. This detected 7 weeks completion treatment, but it could not be 13 treatment. Drug levels did appreciably decrease stored 8 9 months − 10 C. Unequal content assay tubes measurement turbidity visual inspection may explain previously reported 3.0 12.5