Chapter 14. Antifungal Agents

摘要: Publisher Summary This chapter discusses studies focusing on antifungal agents. Amphotericin B administered intravenously continues to be a mainstay in the treatment of systemic mycoses. In chronic pulmonary histoplasmosis, 408 patients was reviewed. spite fact that low doses eradicated organism sputum, dosage 35 mg/kg body weight required decrease case fatality ratio. The mode action pyrrolnitrin studied by use monkey kidney cells, rat liver mitochondria, and beef heart submitochondrial particles. These experiments indicated “reduced pyrrolnitrin” (having an amino group place nitro group) inhibit respiration probably blocking electron transfer between dehydrogenases cytochrome components respiratory chain. extracutaneous sporotrichosis, superiority amphotericin over iodides or hydroxystilbamidine isoethionate indicated. tetraene antibiotic, pimaricin, is effective when applied topically experimental C. albicans oculomycosis rabbits. human medicine, corneal ulcers caused Fusarium Cephalosporium sp. were treated successfully with pimaricin ointment.