Design and statistical optimization of glipizide loaded lipospheres using response surface methodology.

摘要: A 32 factorial design was employed to produce glipizide lipospheres by the emulsification phase separation technique using paraffin wax and stearic acid as retardants. The effect of critical formulation variables, namely levels (X1) proportion in (X2) on geometric mean diameter (dg), percent encapsulation efficiency (% EE), release at end 12 h (rel12) time taken for 50% drug (t50), were evaluated F-test. Mathematical models containing only significant terms generated each response parameter multiple linear regression analysis (MLRA) variance (ANOVA). Both variables studied exerted a influence (p < 0.05) parameters. Numerical optimization desirability approach develop an optimized setting constraints dependent independent variables. experimental values dg, % EE, rel12 t50 found be 57.54 +/- 1.38 mum, 86.28 1.32%, 77.23 2.78% 5.60 0.32 h, respectively, which close agreement with those predicted mathematical models. from followed first-order kinetics characterized Higuchi diffusion model. liposphere developed sustained anti-diabetic activity following oral administration rats.