Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
作者： Jadupati Malakar , Amit Kumar Nayak , Soumita Goswami
DOI: 10.5402/2012/730624
关键词:
摘要: The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 23 factorial design. effects the amounts calcium alginate, HPMC K4M, Carbopol 943 in properties like drug hardness were analyzed optimized. observed responses coincided well with predicted values experimental optimized showed prolonged over 6 hours. These followed first-order model anomalous (non-Fickian) diffusion mechanism.
hindawi.com参考文章(21)
Charalambos G. Varelas, David G. Dixon, Carol A. Steiner, Zero-order release from biphasic polymer hydrogels Journal of Controlled Release. ,vol. 34, pp. 185- 192 ,(1995) , 10.1016/0168-3659(94)00085-9
Richard W. Korsmeyer, Robert Gurny, Eric Doelker, Pierre Buri, Nikolaos A. Peppas, Mechanisms of solute release from porous hydrophilic polymers International Journal of Pharmaceutics. ,vol. 15, pp. 25- 35 ,(1983) , 10.1016/0378-5173(83)90064-9
Nikolaos A. Peppas, Atul R. Khare, PREPARATION, STRUCTURE AND DIFFUSIONAL BEHAVIOR OF HYDROGELS IN CONTROLLED RELEASE Advanced Drug Delivery Reviews. ,vol. 11, pp. 1- 35 ,(1993) , 10.1016/0169-409X(93)90025-Y
Takeru Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension Journal of Pharmaceutical Sciences. ,vol. 50, pp. 874- 875 ,(1961) , 10.1002/JPS.2600501018
Jadupati Malakar, Amit Kumar Nayak, Dilipkumar Pal, Development of cloxacillin loaded multiple-unit alginate-based floating system by emulsion-gelation method. International Journal of Biological Macromolecules. ,vol. 50, pp. 138- 147 ,(2012) , 10.1016/J.IJBIOMAC.2011.10.001
H.-J. Schliep, J. Harting, Beta 1-selectivity of bisoprolol, a new beta-adrenoceptor antagonist, in anesthetized dogs and guinea pigs. Journal of Cardiovascular Pharmacology. ,vol. 6, pp. 1156- 1160 ,(1984) , 10.1097/00005344-198406060-00024
Amit Kumar Nayak, Dilipkumar Pal, Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology. International Journal of Biological Macromolecules. ,vol. 49, pp. 784- 793 ,(2011) , 10.1016/J.IJBIOMAC.2011.07.013
Hagalavadi Shivakumar, Pragnesh Patel, Bapusaheb Desai, Purnima Ashok, Sinnathambi Arulmozhi, Design and statistical optimization of glipizide loaded lipospheres using response surface methodology. Acta Pharmaceutica. ,vol. 57, pp. 269- 285 ,(2007) , 10.2478/V10007-007-0022-8
N. V. Mulye, S. J. Turco, An examination of assumptions underlying the first-order kinetic model for release of water-soluble drugs from dicalcium phosphate dihydrate matrices Drug Development and Industrial Pharmacy. ,vol. 22, pp. 673- 679 ,(1996) , 10.3109/03639049609063223
Mayank Shah, Kamla Pathak, Development and Statistical Optimization of Solid Lipid Nanoparticles of Simvastatin by Using 23 Full-Factorial Design Aaps Pharmscitech. ,vol. 11, pp. 489- 496 ,(2010) , 10.1208/S12249-010-9414-Z