Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, -6, or -10 genes.
作者： Elizabeth J Minton , David Smillie , Paula Smith , Suzanne Shipley , Michael W McKendrick
DOI: 10.1016/J.HUMIMM.2004.11.001
关键词:
摘要: Hepatitis C virus (HCV) commonly causes a chronic infection, but minority of patients are able to clear the and do not run risk developing HCV-induced organ damage. Genetic associations between immunoregulatory cytokines interleukin (IL)-1, -6, -10 with clinical features HCV, including clearance, have been inconsistent. We determined cytokine genotypes in 606 who had serologic evidence HCV exposure, 190 (18%) whom were consistently negative for RNA, indicating successful clearance. There was no significant difference genotype frequencies clearance nonclearance groups IL-1B (-511 +3954), IL-1A (+4845), IL-1RN (+2018), IL-6 (-174), or IL-10 (-1082). conclude that these single nucleotide polymorphisms unlikely play an important, if any, role determining likelihood clearing infection.
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