Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides.
作者： N. V. Ryazantseva , V. V. Novitskii , S. B. Tkachenko , A. P. Zima , V. V. Avdoshina
DOI: 10.1007/S10517-007-0220-X
关键词: Virology 、 Promoter 、 Genotype 、 Allele 、 Immunology 、 Gene 、 Caucasian population 、 Biology 、 Hepatitis B
摘要: Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production immunoregulatory cytokines mononuclear leukocytes (primarily Th2 type). The risk progression and course Caucasian population associated with alleles promoter regions −330G −592A IL-2 IL-10 genes, respectively, as well T/T genotype polymorphic region C590T IL-4 gene. C/C gene C592A shown to be a factor determining resistance long-term persistence hepatitis B C viruses.
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