Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging.

摘要: Flow and oxygenation dependent (FLOOD) MR images of GH3 prolactinomas display large intensity increases in response to carbogen (5% CO 2 /95% O ) breathing. To assess the relative contributions carbon dioxide oxygen this tumour state, 5% air, 100% was monitored by FLOOD MRI pO histography. A 10-30% image increase observed during air breathing, consistent with an blood flow, as a result -induced vasodilation, reducing concentration deoxyhaemoglobin blood. Carbogen caused further 40-50% signal enhancement, suggesting additional improvement due oxygenation. small 5-10% , highlighting dominance vasodilation response. Despite response, non-significant were three gases. Tissue is determined balance supply demand, hence increased flow/oxygenation may not necessarily produce tissue . The level deoxygenation blood, size relating vascular density potential high-oxygen content gases improve tissue.