Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.

摘要: Nicotinamide and carbogen breathing are both effective radiosensitisers in experimental tumour models even more combination. This study was to investigate the feasibility of using agents combination patients measure their effect on oxygenation. Twelve with advanced malignant disease were treated 4-6 g oral nicotinamide (NCT) tablet formulation. Ten these 12 breathed (95% oxygen, 5% carbon dioxide) for up 20 min at presumed peak plasma NCT concentration (Cpeak) had oxygen partial pressure (pO2) measured Eppendorf pO2) histograph. The mean Cpeak values 82, 115 150 micrograms ml-1 doses 4, 5 6 respectively dose dependent. time independent an overall 2.4 h (range 0.7-4 h). toxicity occurred 9 out mild all but one; well tolerated patients. Following only two significant rises (P < 0.05) median pO2. During breathing, eight ten early highly pO2 0.0001), which six continued rise or remained plateau until completion gas breathing. Six hypoxic pretreatment less than mmHg, completely abolished three reduced during In conclusion, generally gave substantial maintained throughout These results should encourage further this potentially useful as clinic.