HOW miRs AND mRNA DEADENYLASES COULD POST-TRANSCRIPTIONALLY REGULATE EXPRESSION OF TUMOR-PROMOTING PROTEIN PLD

摘要: Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). PLD is involved promoting breast cancer growth, proliferation, metastasis gene expression are upregulated carcinoma human samples. In spite all this, ultimate reason to why high cells vs. their normal counterparts remains largely unknown. Until we understand this associated pathways, it will be difficult establish bona fide target explore new potential therapeutic approaches. Recently, our lab has identified several molecular mechanisms by which they involve post-transcriptional control mRNA. First, PA, mitogen, functions mRNA stabilizer that counteracts natural decay degradation. Second, there repertoire microRNAs (miRs) keep translation at low levels cells, but effects change with starvation during endothelial-to-mesenchymal transition (EMT) cells. Third, novel way regulation involving 3'-exonucleases, specifically deadenylase, Poly(A)-specific Ribonuclease (PARN), tags for This would enable accumulation ultimately growth. We review depth emerging field PLD, only recently beginning understood. Since, surprisingly, so little known about related phospholipases (PLC or PLA), knowledge could help understanding how deregulation enzyme impacts tumor