The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur studies-Mac.

作者: Gail A. Greendale , Jennifer B. Unger , John W. Rowe , Teresa E. Seeman

DOI: 10.1111/J.1532-5415.1999.TB03835.X

关键词:

摘要: BACKGROUND: In persons with depression, higher urinary Cortisol is associated lower bone mineral density. OBJECTIVE: To examine the relation between free (UFC) and fractures. SETTING: Community-based samples from Durham, NC, East Boston, MA, New Haven, CT. PARTICIPANTS: 684 men women, aged 70 to 79 at baseline, who were part of MacArthur Study Successful Aging. DESIGN: Cohort study. Participants previous history fractures baseline excluded. MEASURES: The primary exposure variable was overnight (8: 00 p.m. 8: a.m.) UFC (μg/g creatinine) (1988). Outcomes self-reported hip, arm, spine, wrist, or other fracture during follow-up period (1988–1995). Covariates age, gender, race, body mass index, current physical activity, extremity strength, depression subscale Hopkins Symptom Checklist, use cigarettes alcohol. ANALYSIS: Logistic regression used predict occurrence incident (1988–1995) as a function quartiles UFC. Models adjusted for race also multiply remaining covariates listed above. Gender-stratified models that excluded corticosteroid users run. RESULTS: models, levels significantly fractures. Odds (95% Confidence Intervals) increasing UFC, adjusted, were: 2.28 (.91, 5.77); 3.40 (1.33, 8.69); 5.38 (1.68, 17.21). Results not materially influenced by exclusion using corticosteroids. CONCLUSIONS: Higher an independent predictor future fracture.

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